Mupirocin ointment should not be used with intravenous cannulae or at central intravenous sites because of the potential to promote fungal infections and antimicrobial resistance. Risk Associated with Use at Intravenous Sites In common with other polyethylene glycol-based ointments, Mupirocin ointment should not be used in conditions where absorption of large quantities of polyethylene glycol is possible, especially if there is evidence of moderate or severe renal impairment.
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Polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidneys. A separate formulation, Mupirocin nasal ointment, is available for intranasal use. Intranasal use has been associated with isolated reports of stinging and drying. Mupirocin ointment is not formulated for use on mucosal surfaces. Potential for Microbial OvergrowthĪs with other antibacterial products, prolonged use of Mupirocin ointment may result in overgrowth of nonsusceptible microorganisms, including fungi. difficile, and surgical evaluation should be instituted as clinically indicated.
Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C. If CDAD is suspected or confirmed, ongoing antibacterial drug use not directed against C. Careful medical history is necessary since CDAD has been reported to occur over 2 months after the administration of antibacterial agents. CDAD must be considered in all patients who present with diarrhea following antibacterial drug use. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. difficile produces toxins A and B which contribute to the development of CDAD. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. Clostridium difficile-Associated DiarrheaĬlostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents and may range in severity from mild diarrhea to fatal colitis. In the event of a sensitization or severe local irritation from Mupirocin ointment, usage should be discontinued, and appropriate alternative therapy for the infection instituted. In case of accidental contact, rinse well with water. Eye IrritationĪvoid contact with the eyes. Systemic allergic reactions, including anaphylaxis, urticaria, angioedema, and generalized rash, have been reported in patients treated with formulations of Mupirocin, including Mupirocin ointment. Warnings and Precautions Severe Allergic Reactions Mupirocin ointment is contraindicated in patients with known hypersensitivity to Mupirocin or any of the excipients of Mupirocin ointment. Dosage Forms and StrengthsĮach gram of Mupirocin Ointment USP contains 20 mg Mupirocin, USP in a water-miscible ointment base supplied in 22-gram tubes.
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